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cenobamate will minimize the extent or result of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Maximize dose of CYP3A4 substrate, as required, when coadministered with cenobamate.amobarbital will minimize the extent or outcome of fentanyl transdermal by impacting hepatic/intestinal enz